Coarse-Grained Modelling of DNA and DNA Self-Assembly [electronic resource] / by Thomas E. Ouldridge.
Tipo de material:
TextoSeries Springer Theses, Recognizing Outstanding Ph.D. ResearchEditor: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012Descripción: XII, 176 p. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783642305177Trabajos contenidos: SpringerLink (Online service)Tema(s): Physics | Polymers | Nanotechnology | Physics | Biophysics and Biological Physics | Nanotechnology | Polymer Sciences | Statistical Physics, Dynamical Systems and Complexity | Soft and Granular Matter, Complex Fluids and MicrofluidicsFormatos físicos adicionales: Sin títuloClasificación CDD: 571.4 Clasificación LoC:QH505Recursos en línea: de clik aquí para ver el libro electrónico A Novel DNA Model -- Methods -- Finite Size Effects -- Structural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
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