Mȭller, Markus.

Microdialysis in Drug Development [electronic resource] / edited by Markus Mȭller. - XII, 340 p. online resource. - AAPS Advances in the Pharmaceutical Sciences Series, 4 2210-7371 ; . - AAPS Advances in the Pharmaceutical Sciences Series, 4 .

Introduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid- Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis? -- Microdialysis in Internal Organs and Tumors.

ZDB-2-SBL

In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.

9781461448150

10.1007/978-1-4614-4815-0 doi


Medicine.
Pharmaceutical technology.
Biomedicine.
Pharmaceutical Sciences/Technology.
Biomedicine general.

RS380 RS190-210

615.19