TY  - BOOK
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ED  - SpringerLink (Online service)
TI  - Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology 
T2  - Ernst Schering Foundation Symposium Proceedings,
SN  - 9783540794783
AV  - RC254-282 
U1  - 616.994 23
PY  - 2008///
CY  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg
KW  - Medicine
KW  - Human physiology
KW  - Analytical biochemistry
KW  - Oncology
KW  - Medicine & Public Health
KW  - Human Physiology
KW  - Analytical Chemistry
N1  - Mitochondria and Cancer -- Role of the Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression -- The Interplay Between MYC and HIF in the Warburg Effect -- Using Metabolomics to Monitor Anticancer Drugs -- Biomarker Discovery for Drug Development and Translational Medicine Using Metabonomics -- Pyruvate Kinase Type M2: A Key Regulator Within the Tumour Metabolome and a Tool for Metabolic Profiling of Tumours -- Molecular Imaging of Tumor Metabolism and Apoptosis -- Minimally Invasive Biomarkers for Therapy Monitoring -- Use of Metabolic Pathway Flux Information in Anticancer Drug Design -- Cancer Diagnostics Using 1H-NMR-Based Metabonomics -- Human Metabolic Phenotyping and Metabolome Wide Association Studies -- Defining Personal Nutrition and Metabolic Health Through Metabonomics; ZDB-2-SME
N2  - In 1920s, Otto Warburg described the phenomenon of aerobic glycolysis, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburgs hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics)
UR  - http://dx.doi.org/10.1007/978-3-540-79478-3
ER  -