Ouldridge, Thomas E. <br/><br/>
Coarse-Grained Modelling of DNA and DNA Self-Assembly  [electronic resource] / 
by Thomas E. Ouldridge. 
 - XII, 176 p.  online resource. 
 - Springer Theses, Recognizing Outstanding Ph.D. Research,  2190-5053 .
 - Springer Theses, Recognizing Outstanding Ph.D. Research, .
<br/><br/>A Novel DNA Model -- Methods -- Finite Size Effects -- Structural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker. 
<br/><br/>ZDB-2-PHA 
<br/><br/> This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker  the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology. 
<br/><br/><label>ISBN: </label>9783642305177 
<br/><br/><label>Standard No.: </label>10.1007/978-3-642-30517-7  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Physics.<br/>Polymers.<br/>Nanotechnology.<br/>Physics.<br/>Biophysics and Biological Physics.<br/>Nanotechnology.<br/>Polymer Sciences.<br/>Statistical Physics, Dynamical Systems and Complexity.<br/>Soft and Granular Matter, Complex Fluids and Microfluidics.
<br/><br/><label>LC Class. No.: </label>QH505 
<br/><br/><label>Dewey Class. No.: </label>571.4