TY  - BOOK
AU  - 
ED  - SpringerLink (Online service)
TI  - Coarse-Grained Modelling of DNA and DNA Self-Assembly
T2  - Springer Theses, Recognizing Outstanding Ph.D. Research,
SN  - 9783642305177
AV  - QH505 
U1  - 571.4 23
PY  - 2012///
CY  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg, Imprint: Springer
KW  - Physics
KW  - Polymers
KW  - Nanotechnology
KW  - Biophysics and Biological Physics
KW  - Polymer Sciences
KW  - Statistical Physics, Dynamical Systems and Complexity
KW  - Soft and Granular Matter, Complex Fluids and Microfluidics
N1  - A Novel DNA Model -- Methods -- Finite Size Effects -- Structural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker; ZDB-2-PHA
N2  - This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker  the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology
UR  - http://dx.doi.org/10.1007/978-3-642-30517-7
ER  -