Therapeutic Kinase Inhibitors [electronic resource] / edited by Ingo K. Mellinghoff, Charles L. Sawyers.
Tipo de material:
TextoSeries Current Topics in Microbiology and Immunology, 355Editor: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012Descripción: X, 234 p. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783642282966Trabajos contenidos: SpringerLink (Online service)Tema(s): Medicine | Oncology | Biomedicine | Cancer ResearchFormatos físicos adicionales: Sin títuloClasificación CDD: 614.5999 Clasificación LoC:RC261-271Recursos en línea: de clik aquí para ver el libro electrónico Springer eBooksResumen: Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as ǣchemotherapyǥ and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates. This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editors invited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors hopethese lessons will be instructive for the novice as well as the expert.
Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as ǣchemotherapyǥ and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates. This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editors invited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors hopethese lessons will be instructive for the novice as well as the expert.
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