000			04547nam a22004935i 4500
003			DE-He213
005			20191011014035.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020	6	4	_a9780387232263 _9978-0-387-23226-3
024	8	7	_a10.1007/b100942 _2doi
050	8	4	_aQH345
050	8	4	_aQD415-436
072	8	7	_aPSB _2bicssc
072	8	7	_aSCI007000 _2bisacsh
082			_a572 _223
100	8	1	_aHarris, J. Robin. _eeditor. _910824
245	9	7	_aAlzheimers Disease _h[electronic resource] : _bCellular and Molecular Aspects of Amyloid / _cedited by J. Robin Harris, Falk Fahrenholz.
001			000044305
300	6	4	_aXVII, 409 p. _bonline resource.
490	8	1	_aSubcellular Biochemistry, _x0306-0225 ; _v38
505	8	0	_aThe Contribution of Microscopy to the Study of Alzheimers Disease, Amyloid Plaques and A? Fibrillogenesis -- Transgenic Mouse Models for APP Processing and Alzheimers Disease: Early and Late Defects -- Oxidative stress in Alzheimers Disease: Implications for Prevention and Therapy -- ?-Secretase, APP and A? in Alzheimers Disease -- The Non-Amyloidogenic Pathway: Structure and Function of ?-Secretases -- Amyloid ? Degradation: A Challenging Task for Brain Peptidases -- The Protective Role of Vitamin E in Vascular Amyloid ?-Mediated Damage -- Amyloid Accumulation and Pathogensis of Alzheimers Disease: Significance of Monomeric, Oligomeric and Fibrillar A? -- Cholesterol and Amyloid ? Fibrillogenesis -- Alzheimers ?-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding -- The Aluminium-Amyloid Cascade Hypothesis and Alzheimers Disease -- Amyloid-? Metal Interaction and Metal Chelation -- The Interaction of Amyloid-? with ApoE -- Clusterin and Alzheimers Disease -- Acetylcholinesterase Interaction with Alzheimer Amyloid ? -- Membrane Disordering Effects of ?-Amyloid Peptides -- The Role of Alzheimer A? Peptides in Ion Transport Across Cell Membranes -- Amyloid Inhibitors and ?-Sheet Breakers -- Cholesterol and Alzheimers Disease: Statins, Cholesterol Depletion in APP Processing and A? Generation -- Phosphorylated Amyloid-?: the Toxic Intermediate in Alzheimers Disease Neurodegeneration.
520	6	4	_aThis book contains a survey of present-day research into the biomedical fundamentals of Alzheimers disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-Ȗ production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-Ȗ oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-Ȗ on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the Ȗ-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-Ȗ phosphorylation receives detailed attention. Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-Ȗ, of direct relevance to Alzheimers disease.
650	8	0	_aLife sciences. _910825
650	8	0	_aNeurosciences. _910826
650	8	0	_aBiochemistry. _94385
650			_aLife Sciences. _910827
650			_aBiochemistry, general. _94389
650			_aNeurosciences. _910826
700	8	1	_aFahrenholz, Falk. _eeditor. _910828
710	8	2	_aSpringerLink (Online service) _910829
773	8	0	_tSpringer eBooks
776			_iPrinted edition: _z9780387232256
830	8	0	_aSubcellular Biochemistry, _x0306-0225 ; _v38 _910830
856			_uhttp://dx.doi.org/10.1007/b100942 _zde clik aquí para ver el libro electrónico
264	8	1	_aBoston, MA : _bSpringer US, _c2005.
336	6	4	_atext _btxt _2rdacontent
337	6	4	_acomputer _bc _2rdamedia
338	6	4	_aonline resource _bcr _2rdacarrier
347	6	4	_atext file _bPDF _2rda
516	6	4	_aZDB-2-SBL
999			_c44034 _d44034
942			_c05