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020 6 4 _a9781441973689
_9978-1-4419-7368-9
024 8 7 _a10.1007/978-1-4419-7368-9
_2doi
050 8 4 _aQP351-495
072 8 7 _aPSAN
_2bicssc
072 8 7 _aSCI070000
_2bisacsh
072 8 7 _aMED057000
_2bisacsh
082 _a573.8
_223
100 8 1 _aGallo, Gianluca.
_eeditor.
_963892
245 9 7 _aNeurobiology of Actin
_h[electronic resource] :
_bFrom Neurulation to Synaptic Function /
_cedited by Gianluca Gallo, Lorene M. Lanier.
001 000053146
300 6 4 _aVIII, 282 p.
_bonline resource.
490 8 1 _aAdvances in Neurobiology,
_x2190-5215 ;
_v5
505 8 0 _aIntroduction to the Neurobiology of Actin -- The Neuronal Actin Cytoskeleton and the Protrusion of Lamellipodia and Filopodia -- Regulation of Actin Filaments During Neurite Extension and Guidance -- Functions of Myosin Motor Proteins in the Nervous System -- Microtubule-Actin Interactions During Neuronal Development -- Working with Actin: Methodological Approaches for the Study of Actin in Neurons -- Functions of the Actin Cytoskeleton in the Early Embryology of the Nervous System -- Actin Cytoskeletal Regulation in Neuronal Migration -- Actin and Neuronal Polarity -- Actin at the Synapse: Contribution to Pre and Post-synaptic Functions -- Actin and Diseases of the Nervous System -- Signal Transduction Pathways: From Receptor to the Actin Cytoskeleton.
520 6 4 _aNeurons are characterized by a complex, dynamic and highly polarized morphology. Actin and its regulatory proteins are the most abundant set of proteins within cells, and they form one of the major cytoskeletal systemsthe actin filament cytoskeleton. While much has been learned about the roles of the actin cytoskeleton in non-neuronal cells, our understanding of the full spectrum of the functions of actin in neurons is far from complete. This book is an introduction to the interface between the actin cytoskeleton and the myriad of issues fundamental to the understanding of nervous system function. Neurobiology of Actin: From Neurulation to Synaptic Function opens with a chapter that presents the fundamental concepts required to appreciate the details of the molecular machinery that regulates actin in a cellular context, setting the stage for the first part of the book which reviews the neurobiology of actin at the cellular level. The second section of the book then discusses the functions of actin in the context of neurobiological issues ranging from early development to synaptic function and disease states of the nervous system. This text is intended for neuroscientists interested in investigating the actin cytoskeleton in the context of their particular neuroscience research program, and its chapters are cross-referenced in order to assist readers in finding relevant information that is covered in greater depth in other chapters.
650 8 0 _aLife sciences.
_963893
650 8 0 _aNeurobiology.
_99133
650 _aLife Sciences.
_963894
650 _aNeurobiology.
_99133
700 8 1 _aLanier, Lorene M.
_eeditor.
_963895
710 8 2 _aSpringerLink (Online service)
_963896
773 8 0 _tSpringer eBooks
776 _iPrinted edition:
_z9781441973672
830 8 0 _aAdvances in Neurobiology,
_x2190-5215 ;
_v5
_963897
856 _uhttp://dx.doi.org/10.1007/978-1-4419-7368-9
_zde clik aquí para ver el libro electrónico
264 8 1 _aNew York, NY :
_bSpringer New York,
_c2011.
336 6 4 _atext
_btxt
_2rdacontent
337 6 4 _acomputer
_bc
_2rdamedia
338 6 4 _aonline resource
_bcr
_2rdacarrier
347 6 4 _atext file
_bPDF
_2rda
516 6 4 _aZDB-2-SBL
999 _c52876
_d52876
942 _c05