000 02741nam a22005175i 4500
003 DE-He213
005 20191014021612.0
007 cr nn 008mamaa
008 120707s2012 gw | s |||| 0|eng d
020 6 4 _a9783642305177
_9978-3-642-30517-7
024 8 7 _a10.1007/978-3-642-30517-7
_2doi
050 8 4 _aQH505
072 8 7 _aPHVN
_2bicssc
072 8 7 _aPHVD
_2bicssc
072 8 7 _aSCI009000
_2bisacsh
082 _a571.4
_223
100 8 1 _aOuldridge, Thomas E.
_eauthor.
_9194153
245 9 7 _aCoarse-Grained Modelling of DNA and DNA Self-Assembly
_h[electronic resource] /
_cby Thomas E. Ouldridge.
001 000072292
300 6 4 _aXII, 176 p.
_bonline resource.
490 8 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
505 8 0 _aA Novel DNA Model -- Methods -- Finite Size Effects -- Structural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker.
520 6 4 _aThis thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
650 8 0 _aPhysics.
_9194154
650 8 0 _aPolymers.
_913475
650 8 0 _aNanotechnology.
_99777
650 _aPhysics.
_9194154
650 _aBiophysics and Biological Physics.
_99136
650 _aNanotechnology.
_99777
650 _aPolymer Sciences.
_913477
650 _aStatistical Physics, Dynamical Systems and Complexity.
_912503
650 _aSoft and Granular Matter, Complex Fluids and Microfluidics.
_912853
710 8 2 _aSpringerLink (Online service)
_9194155
773 8 0 _tSpringer eBooks
776 _iPrinted edition:
_z9783642305160
830 8 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
_9194156
856 _uhttp://dx.doi.org/10.1007/978-3-642-30517-7
_zde clik aquí para ver el libro electrónico
264 8 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
336 6 4 _atext
_btxt
_2rdacontent
337 6 4 _acomputer
_bc
_2rdamedia
338 6 4 _aonline resource
_bcr
_2rdacarrier
347 6 4 _atext file
_bPDF
_2rda
516 6 4 _aZDB-2-PHA
999 _c72022
_d72022
942 _c05